What was the toughest symptom you've had to tell a family regarding their child? Why was this challenging, and how did you handle it?

"I had to tell parents of a young boy that he had Klinefelter's (XXY - trisomy disorder) and he would not be able to have biological children of his own. Furthermore, there might be a chance that he could develop some mild female behaviors and characteristics when he hits puberty. It was difficult to see the parents get emotional as I explained the disorder but I stayed calm and offered any guidance that I could - articles pertaining to the syndrome, local support groups and some things to think about as the boy grows up."