This question intends on finding out more about your past work experience and if any of it is related to this job. The answer to this question is pretty simple and needs to be answered honestly. There is always a possibility that the hiring manager might ask for references and do a background check and thus an honest answer is always good.
For answering this question, tell the hiring manager how long you have worked in a similar role or how much you know about this job and your reason for shifting jobs (this is an exception; you may give your answer without this too).