The first thing to mention in your response here is that you are aware that you will work long hours, be required to work on days off to attend meetings, and spend countless hours driving. Assure your interviewer that you are both physically and mentally prepared for these demands and even welcome them. If you have similar experience working under similar demands on the job, be sure to talk about how you successfully navigated that work. Also, don't hesitate to talk about how your friends and family are ready to help you succeed given the requirements of the job.

"Yes, I'm confident I will be able to handle all of the demands of the job. As you can see from my resume, I've spent six years of my career doing national sales and I'm excited to get back on the road in sales after being out of the game for four years. With this position, I love that I will still be able to be home most nights now that we have a growing family. I have a spouse who is extremely supportive of this career move for me as well."