Focus on being direct and honest, and explain why you left your last place of employment. If you gave notice, were laid off, or fired, describe the circumstances behind your leaving. Be sure to end your response on a positive note and tell the interviewer how you are excited to have the opportunity to interview for the position with their company.

"I really enjoyed my last job, but I gave my two weeks' notice and left on good terms last month. I left because I had a two-hour commute every day, and it was starting to impact my family. When I started my previous job, my commute was 15 minutes. However, my mother became ill, and we moved here to be closer to her. That is one of the reasons I am applying for this position, as your hospital is only five minutes from my home."