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Pharmaceutical Manufacturing Mock Interview

Question 27 of 30 for our Pharmaceutical Manufacturing Mock Interview

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Question 27 of 30

What are some reasons that could cause chipping in tablet manufacturing?

"Chipping could occur during tablet manufacturing by the tablet sticking to the punch face, which could be as a result of poor lubrication, or insufficient drying. Respectively, the remedy to this cause of chipping would be to properly dry the granules and to use the right amount of lubrication."

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How to Answer: What are some reasons that could cause chipping in tablet manufacturing?

Advice and answer examples written specifically for a Pharmaceutical Manufacturing job interview.

  • 27. What are some reasons that could cause chipping in tablet manufacturing?

      How to Answer

      Chipping occurs when there is breaking of the edges of the tablet during the manufacturing process. . Chipping can occur as the tablet leaves the press or during subsequent operations such as coating. Share some reasons that chipping may occur and any remedy, if possible.

      1st Answer Example

      "Chipping could occur during tablet manufacturing by the tablet sticking to the punch face, which could be as a result of poor lubrication, or insufficient drying. Respectively, the remedy to this cause of chipping would be to properly dry the granules and to use the right amount of lubrication."

      2nd Answer Example

      "One cause of chipping could be that the granules are too dry granules which results in chipping when the tablet is under the pressure of the press. Promoting plasticity through moistening the granules should help resolve this issue."

      Anonymous Interview Answers with Professional Feedback

      Anonymous Answer

      "We can list the reasons as follows: Tablet tooling is worn or damaged. The tablet edges are too sharp. Tablet friability is not optimal for a stressful process such as film coating (soft tablet, not enough binder, granules are too dry ). Pan speed is too high, causing increased edge wear. The coating cannot be applied fast enough to allow coating build-up to protect edges."

      Jaymie's Feedback

      These are all accurate causes for chipping. Great job.

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