As with any interview question, you should focus on being completely honest in your response. As embarrassing as it may be, if you do not think you will pass the drug test, you need to let the interviewer know that now. If passing the drug test will not be an issue, assure the interviewer that you will pass the test because you do not use drugs. Some states also allow Cigna to test for nicotine in your system. The list of states that allow this is on the company website. If you have anything on your record, you must also disclose that as the investigators will discover any past criminal history.