This position requires a background check and drug screen. Do you have any concerns with this policy?

The hotel company is going to run references, do a background check, and drug screen. The interviewer needs to make sure that there are no skeletons in the closet that have not emerged during the interview. Be forthright about any issues that you have. It may cost you the chance at a job, but the hiring manager will appreciate your not wasting their time.

"There are no issues that I am aware of. My background check should pass with flying colors and I do not use drugs."