Hyatt screens every applicant with a background check and drug screen. Is there any issue that we should be made aware of?

Every hotel chain performs some sort of background check and in this day and age, drug screenings are very common. The interviewer is trying to give you a heads up in case there is an issue that might prevent you from passing. If there is a problem, it is always best, to be honest, and forthcoming with the hiring manager. If there is no issue, then this question should be answered directly with confidence.