Starting a new role is always a challenge. Not only does the interviewer want to ensure your expectations are grounded and fueled with thorough research; they want to understand why you perceive it as a challenge and how you look at that challenge - negatively or positively. A motivated, career-minded professional will look forward to those challenges, which serve as milestones in career growth. Try to frame those anticipated challenges with enthusiasm and optimism. Explain why these are significant and worth mentioning.