Prior to applying for a role as a Ticket Agent, it is important to know that Ticket Agents work shifts that include nights, weekends, and holidays, as airlines are a business that flourish during these times.
Should your interviewer ask this question, it is highly likely you will have to work such hours. As such, the interviewer will expect you to be able to work as needed. As you answer, be sure to reiterate that you are flexible to be able to work any hours that you may be scheduled. If you do have any sort of time commitments regarding family or other personal matters, now is the time to disclose those as well. Keep in mind that a simple answer of not being able to work weekends could immediately disqualify you for the role.