With this question, the interviewers will gauge your flexibility and expectations. Before answering, be clear on the expectations of the role. Make sure you have thoroughly researched this position. If, after adequate research, the expectations on availability remain unclear, now would be the time to ask. Keep in mind that, in most states, an employer cannot demand that an employee work more than 44 hours per week. Yet, depending on the position you are applying for, there may be a high demand for less desirable shifts, expectations for putting in overtime or weekend hours, or expected on-call coverage when experiencing staff shortages. Be honest. It's better to discuss these things in an interview before making commitments you can't keep. If you have other priorities or demands on your time that aren't conducive to working lots of overtime or covering other shifts, clarify this now.