I try to find out why the patient is being aggressive and why they are refusing medications. More often than not there is a reason for their behavior, and we just need to find out what it is. I will try to reason with them and educate them on why they need the specific medication because they may not understand that either. Finally, sometimes it's best to let the patient cool down and try to discuss with them a little bit later when they are more willing to listen. If all that fails, we need to have a discussion with the physician to determine the best course of action.