Whenever you ask a question this targeted, there will be a risk of hearing something you don't want to hear. Be sure that you are prepared to accept feedback on your application, your qualifications, or even your interviewing skills.
By asking this question, you are asking the interviewer to identify where your application is weak so that you have the opportunity to correct your reply or give a more precise answer on that particular subject.
Be sure to thank the interviewer for their feedback and then take some time to overcome their objection. For instance, if the interviewer says they feel that your Excel skills are not strong enough, you could say: 'Thank you for that feedback. Perhaps I was more humble regarding my Excel skills than I should have been. I am currently ranked as an intermediate user. I will be enrolling in a three-week online program immediately to raise my skills to meet the expert level your organization expects.'
