As a nurse, you should be used to working odd and unusual schedules unless you have only worked in a clinic or doctor's office with a traditional schedule. The NHS makes every effort to be flexible with your schedule and allow their team members to have a healthy work/life balance. However, some positions require you to work weekends and public holidays, which will be listed on the job announcement. The interviewers want to see that you read the job announcement in its entirety and understand you would be required to work public holidays and weekends.