Assure the interviewer you understand the nature of the business and that working weekends is part of the job. Let them know that you are flexible with your schedule and willing to work whatever hours they need, including weekends. If you have a personal obligation, such as caring for a child or family member on the weekends, describe your situation to the interviewer and explain how you will look for help with your child or family member on the weekends you need to work. If you are honest in the interview, the interviewer will understand if there are some weekends you might not be able to work.

"Yes, I am available to work weekends when needed. I understand the nature of this profession and have no problem working weekends if needed. I have a class I take every Saturday for the next six months, but my professor will let me make up the class if I have to work."