This question evaluates your emotional maturity. Your grades impact your future success, and this may have a more significant impact in the medical field than in other professions. Everyone processes the stress and disappointment of setbacks differently. Disappointment is natural, yet allowing those emotions to dictate your behavior won't move you closer to success. But, taking knocks in stride, examining how you could improve your performance, and distilling what there is to learn from such experiences exhibits emotional maturity and a continual desire for personal and professional growth. Share with your admissions interviewers how you manage such feelings, what you learn from those experiences, and how you perceive these events as a learning opportunity.