This position requires you to work various shifts and hours, including weekends, nights, and bank holidays. If chosen for the position, will this be an issue for you?

If working bank holidays, nights, and weekends are required for the position, those requirements should have been listed on the job announcement. The interviewers want to ensure you read the conditions and understand the schedule you will be required to work if chosen for the position. Assure the interviewers that you have no issues working an atypical schedule.