How would you deal with XYZ clinical presentation?

If you feel confident in your answer, deliver it accordingly! If you aren't sure how to answer the question, be honest about that, acknowledging that it's not an area you have experience in. Of course, you'll want to express your interest and willingness to learn about it. Not knowing the answer to a clinical question does not ruin your chances of matching with the program. The interviewers know not everyone has had experience with every disease presentation and will appreciate your honesty.

If you're familiar with the condition:

"If a patient were admitted with XYZ, I would...." Continue your answer with the specific details of how you would manage a patient with a specific condition."

If you're uncertain how to answer the question:

"That isn't a condition I've had many experiences with during residency, although I do want to learn more about managing it."