Are you available to work weekends and holidays when needed?

Assure the interviewer you understand the nature of the business and that working weekends is part of the job. Tell them you are flexible with your schedule and willing to work whatever hours they need, including weekends and holidays.

"Yes, I am available to work weekends and holidays when needed. I understand the nature of this industry and have no problem working weekends and holidays. I take a class every Saturday, but my professor will let me make up the class if I have to work."

"Yes, absolutely. Patient care needs don't stop on the weekends or over holidays, and I am available to work during those times."