Your interviewers are trying to understand and predict how you will work in the face of adversity. They want to know that you will rise to the occasion when the going gets tough.

You must be able to give a concrete example of a setback or failure you experienced during residency training and then show how you were able to improve your circumstances. You should be able to show that you learned from the failure and that you won't make the same mistake again. As long as you can do this, your interviewers know that setbacks happen to any physician in training, and explaining how you handled your success will go a long way with your interviewing team.