Do you have any questions for us?

"Yes, I do. Thank you for asking. I understand that you've recently expanded your laboratory space with an entirely new wing. How have you integrated this new space into your team's day-to-day operations, and what additional changes can be expected for the team in the coming months and years?"

Take advantage of this question! This is an excellent opportunity to show your interviewer that you are genuinely interested in the position, and it's a good time to show off some of your research about the company. It is also a chance for you to ask about the hiring timeline, which will help you with your timeline for following up. Prepare a list of two to three questions in advance, ensuring the answers to your questions are not easily found with a little research. You can also take mental notes throughout the interview to ask targeted questions about something you discussed, which will impress your interviewer and show that you were listening.

What is your experience with following procedure, preparing for, and being involved in a regulatory audit and/or inspections of any kind?

"I have prepared for a Clinical Laboratory Improvement Amendments (CLIA) inspection by closely following all protocols while having good documentation practices. In addition, all proficiency testing is kept up-to-date. Although reagents and documentation are organized and well maintained throughout the year, I perform a walk-through of the laboratory before any inspection and review all documentation for errors."

As a Clinical Research Associate, you will likely encounter an audit or inspection of some kind, whether internal or external. The type of audit and/or inspection varies depending on the type of organization and the type of lab testing done at the facility. Your answer should reflect your experience and your awareness of expectations for the position you are interviewing for. Many companies and industries are subject to regulatory oversight and audits, and employees must be knowledgeable and capable in these areas. Additionally, having experience with audits and inspections can demonstrate attention to detail, compliance with regulations, and the ability to work effectively under pressure.

What have you done to further your professional development in the past 5 years?

"After a few years working in the lab and gaining hands-on experience, I felt it was time to level up my skills. I started supporting the interns in our lab and enjoyed the opportunity to mentor others and monitor their progress. I researched continuing my formal education and found a master's program that offered online classes. I continued gaining practical, hands-on experience in the lab during the day and furthering my knowledge and skillset in the evening. I graduated this time last year and have taken on more of a supervisory role on my team since then. In the future, I will continue to develop my leadership skills by attending leadership workshops designed for Clinical Research Associates and take on more managerial responsibilities."

Since 2022, turnover and burnout have become rampant in the clinical trials industry as the percentage of clinical trials has increased. However, studies have shown that Clinical Research Associates and other clinical trial staff have improved retention rates when they pursue opportunities to grow their skills. The interviewer asks this question to determine if you are driven and motivated to progressing professionally. Tell the interviewer about any certifications, career-related conferences, leadership workshops, or higher education you have participated in or achieved in the past five years. If you haven't attended many seminars or workshops, then consider how you have gone above and beyond in your work to learn from others. You might have a mentor, or maybe you've briefly stepped away from your career to try a new job in the hopes of gaining a unique skill set that will complement your profession. Whatever you have done to grow professionally in the past five years should be shared with the interviewer, no matter how small it seems.

How would you respond if a trial participant asked you why they should participate in a clinical trial?

"I would tell the participant there are several reasons why participating in a clinical trial can be beneficial. First, I would tell them they may have access to new treatments and medications that are not available to the general public. Additionally, by participating in a clinical trial, they will be contributing to the advancement of medical research and helping to improve the lives of others who may benefit from these treatments in the future. I would explain that clinical trials are closely monitored to ensure the safety of participants, so they can feel confident they are in good hands. Overall, participating in a clinical trial is a great way to positively impact the world while potentially benefiting from cutting-edge medical advancements. However, I would also clarify that their participation is their choice and a decision they must make themselves."

How you respond to this question will give the interviewer insight into your communication and interpersonal skills. In your role as a Clinical Research Associate, the interviewer wants to hear that you would inform the trial participant that participating in a clinical trial is an opportunity to potentially receive access to new treatments that are not yet available to the general public. Clinical trials are also crucial for advancing medical science and improving patient outcomes in the future. Additionally, participating in a clinical trial can provide a sense of fulfillment, knowing that you are contributing to the development of new treatments and helping others who may benefit from them. Ultimately, the decision to participate in a clinical trial is personal and should be based on the individual's values and health goals.

What is the difference between accuracy and precision?

"Precision is the agreement between a series of measurements obtained from multiple sampling of the same homogeneous sample under the prescribed conditions, while accuracy is the proximity of an individual measurement to the 'true' value as determined by the reference method/gold standard. Of course, accuracy and precision are incredibly important in a laboratory setting."

Accuracy and precision are often used interchangeably but refer to different concepts. Accuracy refers to how close a measurement is to the true value or target. Precision, on the other hand, refers to how consistent a set of measurements are. In other words, accuracy is about being correct, while precision is about being consistent. Both accuracy and precision are important in many fields, such as science, engineering, and medicine. The interviewer is looking for how you delineate the difference between these two terms. You can reply by either providing an example that illustrates that you understand the difference and can relate it to real-world situations or by simply describing it. To further emphasize your understanding of the terms and their relevance to the position, follow up by saying why both are relevant and important in a laboratory setting.

How do you describe your job to others who are unfamiliar with this line of work?

"If someone is unfamiliar with my line of work, I explain how my job involves monitoring and coordinating clinical trials to ensure they comply with protocol, regulations, and ethical standards. I describe how I am responsible for reviewing study documents, collecting and analyzing study data, and communicating with participants and stakeholders. Overall, my role is to ensure the safety and efficacy of the clinical trial process."

While clinical trials are recorded as far back as 500 BC, many people not in the medical field or healthcare industry do not understand what is entailed in a clinical trial and what the different job titles represent. The interviewer asks this question to understand your communication skills and how you explain what you do to others. You want to briefly describe your job in easy-to-understand terminology while showing your passion for your line of work. For example, you could describe your work as a healthcare professional who plays a vital role in developing new medical treatments and therapies. You work closely with physicians and other medical professionals to ensure clinical trials are conducted safely and effectively. Then, you could explain that your responsibilities include monitoring study participants, collecting and analyzing data, and ensuring that study protocols are followed.

Are you a detail-oriented person?

"Absolutely - I am always focused on the details in nearly all areas of my life. Paying attention to detail allows me to see and learn patterns that explain how much of the world operates. I enjoy working in the scientific field because it encourages me to fully embrace the details, whether hands-on in the lab or back at my desk creating workflows and conditions to streamline my work and allow me to bring the research to life in reports and on-screen."

The interviewer may ask if you are a detail-oriented person as a Clinical Research Associate because attention to detail is crucial in this role. As a CRA, you will be responsible for reviewing and analyzing data, ensuring compliance with regulations, and monitoring study progress. Any errors or oversights could have serious consequences, so being detail-oriented is essential for success in this position. It's important to emphasize your ability to pay close attention to details and provide examples of how you have demonstrated this skill in previous roles.

Tell me about the data entry programs you are familiar with.

"I am familiar with two data entry programs; Oracle Clinical and Clintrial. I picked up both programs quite easily, and I assure you I will do the same if I need to be trained in something different. If you don't mind me asking, which data entry programs does your organization use?"

Clinical Research Associates use several data entry programs to input and manage data. Some commonly used programs include Medidata Rave, Oracle Clinical, and ClinCapture. These programs are designed to provide a user-friendly interface for data entry and efficient data management and reporting capabilities. In addition, some programs may also offer features such as data validation, edit checks, and user-defined fields to ensure the accuracy and consistency of data. Overall, the choice of a data entry program may depend on the specific needs and requirements of the clinical trial, as well as the preferences of the research team. The interviewer wants to know what programs you are familiar with to see if you will need additional training on the program the organization uses and prefers.

What part of your job is the most rewarding?

"As a Clinical Research Associate, the most rewarding aspect of my job is the opportunity to directly contribute to developing new medical treatments and technologies. Knowing that my work could potentially improve the lives of countless people is incredibly fulfilling and motivating. Additionally, working as part of a team of dedicated professionals who share the same goals and values makes the job both challenging and rewarding. It's a great feeling to know that I'm making a difference in the world through my work, and I could not see doing anything else!"

Interviewers often ask what part of your job as a Clinical Research Associate is most rewarding because they want to know what motivates you and what you find fulfilling about your work. By understanding what aspects of the job you enjoy most, they can gain insight into your personality and work ethic, which can help them determine if you are the right fit for the position. It also gives them an idea of what they can expect from you in terms of dedication and job satisfaction. When answering this question, be honest and specific about what you find rewarding in your profession.

What is the purpose of a polymerase chain reaction (PCR)? Please provide an example of when you've run one in the past.

"PCR stands for Polymerase Chain Reaction, a technique used to amplify a specific DNA sequence. The process involves repeatedly heating and cooling a reaction mixture containing DNA, primers (short DNA sequences that bind to the target sequence), and a particular enzyme called Taq polymerase. This enzyme copies and extends the primers, creating new DNA strands that match the target sequence. In the past, I have run PCRs using a thermal cycler machine, which is programmed to control the temperature cycles needed for the reaction. I carefully prepared the reaction mixture, including optimizing the concentration of primers and DNA template, and followed the thermal cycling protocol to ensure the successful amplification of the target DNA. It is essential to maintain sterile conditions and prevent contamination during PCR, as even a tiny amount of foreign DNA can affect the accuracy of the results. Overall, PCR is a powerful tool in molecular biology that allows researchers to generate large amounts of specific DNA sequences for further analysis."

PCR is a fundamental technique used in many fields, including medical research and diagnosis, forensic science, and biotechnology. Understanding the purpose and basic principles of PCR is essential for anyone working in these fields. Your interviewer will likely ask various knowledge-based questions to know how well you understand the concept and can explain it to others. Additionally, the interviewer is interested in learning how you have run one in the past, as this can provide valuable insight into your skills and experience.

When receiving a new piece of equipment in the lab, give a brief explanation of what you would do to verify that the equipment works properly for its intended test.

"The first thing I do when receiving new equipment is to carefully inspect it for any physical damage or defects. Once I have confirmed that it appears in good condition, I then follow the manufacturer's instructions to determine the appropriate installation and setup procedures. I follow these instructions carefully, taking note of any special requirements or considerations. Once the equipment is set up and connected, I will run a series of tests to ensure it functions properly. This may include running calibration tests, checking for proper temperature and pressure readings, and verifying that data is collected and recorded accurately. If any issues or problems are detected during this testing process, I would consult the manufacturer's troubleshooting guide or contact their customer support team for assistance. By taking these steps, I can ensure the new equipment is working properly and will be able to provide accurate and reliable results for the lab's research and testing needs."

Laboratories upgrade and receive new equipment based on testing needs. The interviewer wants to determine how well and thoroughly you handle new equipment and how you can explain your process to others, highlighting your communication skills. The interviewer wants to see that you know what needs to occur to ensure the accuracy and precision of results in all new equipment received. It is best to answer with a real example if you have one.

In the scenario where your quality control fails, what troubleshooting steps would you take?

"Since quality controls are necessary for all experiments, it's imperative that both the negative and positive control are successful. Depending on which one fails, I will troubleshoot accordingly. For example, if the positive control fails, I would first check whether or not I added the sample, as human error is a common reason for failure. If there is an internal control for all samples, including controls, I would ensure it is detectable. Other positives on the run eliminate reagent and machine errors of any sort."

This question will let the interviewer know whether or not you understand what quality control is and provide an opportunity for you to impress with your troubleshooting and critical thinking skills. Suppose you have a specific example to illustrate your knowledge. If so, clearly outline your process and steps so you aren't going back and forth in your response.

Give an example of the types of metadata and/or data analysis you are familiar with and have used in previous positions.

"When studying gene expression in tumor samples, I utilized the GenePattern software to determine which genes were highly expressed in patient tumor samples. The data was visualized using the HeatMapViewer tool within the software. The metadata for the samples was kept in an Excel spreadsheet along with summary results. This analysis led to further investigations based on the genes that were likely biomarkers."

In this question, your interviewer is looking for how well you bring knowledge to application. If the current position is for a breast cancer research lab, the best answer will show an awareness of the types of data sets you might encounter in that setting. Give a specific example that proves your experience level, awareness, and understanding of how it relates to the position you're interviewing for.

When your boss asks you to get 5 aliquots each of 5 different samples to deliver to another department, what is being asked and how would you perform the task?

"When obtaining aliquots of RNA, I get a bucket of ice to thaw RNA samples, then working in the proper RNA designated location, I would pipette 15ul aliquots per 5 samples into five different tubes for a total of 25 samples. Finally, I'd deliver either on ice if taking over immediately or in a box of dry ice."

The interviewer will ask situation-based questions to test your knowledge and how you explain your process to others. This question confirms that you know common lab terminology, as you should know what an aliquot is. Also, it provides the interviewer with a sense of how you perform everyday laboratory tasks. As with any situation-based questions, clearly outline your process so you do not skip around and appear disorganized.

How would you describe Good Laboratory Practices (GLP) to a new employee?

"When describing Good Laboratory Practice (GLP) to a new employee, I emphasize the importance of maintaining high standards of accuracy, precision, and reliability in all laboratory procedures. I explain that GLP is a set of principles that govern scientific research, ensuring that all data generated is valid, verifiable, and free from contamination or errors. This involves following strict protocols for handling, storing, and analyzing samples and maintaining detailed records of all experimental procedures and results. By adhering to GLP guidelines, we can ensure that our research is conducted with the highest level of integrity and that our findings are trustworthy and scientifically sound."

This question allows for some creativity, so don't be afraid to have some fun with it. Your response lets the interviewer know your teaching ability, your understanding of laboratory terminology, and how well you explain concepts and guidelines to others. Here is an example of how you could describe GLP to a new employee:'When it comes to working in a laboratory, it's important to follow Good Laboratory Practices (GLP) to ensure safety and accuracy in your work. These practices include keeping a clean and organized workspace, properly labeling and documenting all materials and procedures, and following established protocols for testing and analysis. By adhering to GLP, we can ensure that our results are reliable and accurate and that we are able to produce high-quality work that meets the standards of our industry. It may take some time to get used to these practices, but with practice and diligence, they will become second nature and help us to be successful in our work.'

Suppose you hear that a coworker is talking poorly about you behind your back. How would you respond?

"If I found out that a coworker was talking poorly about me behind my back, I would feel hurt and disappointed. However, I would approach the situation calmly and professionally. I would first try to understand why they felt the need to talk negatively about me and see if I could do anything to address their concerns. If the situation cannot be resolved, I would speak with a supervisor or HR representative to ensure the behavior stops and to protect my reputation. Ultimately, it is important to maintain a positive and respectful work environment, and I would do my best to uphold those values in this situation."

There are several reasons an interviewer will ask a situational question. Firstly, they may want to gauge your ability to handle workplace conflict in a professional manner. Secondly, they may want to see how you react to a potentially uncomfortable situation. It's essential to approach this scenario with tact and diplomacy and to address the issue directly with your coworker rather than escalate it further. However, show the interviewer you are willing to speak with a supervisor or HR personnel if the issue cannot be resolved. Ultimately, demonstrating your ability to handle conflict calmly and professionally can make you a valuable asset to any team.

Describe a time when you made a pipetting error and what you did to fix it.

"When I pipette in the lab, I am deliberate and slowly pipette the necessary volume. There have been times that I've used the incorrect pipette size for the volume needed. Still, I notice this immediately as I know how various amounts appear in the correct vs. incorrect pipette. For example, it's obvious to me what 1mL looks like vs. 10ul. I would know immediately if the wrong pipette is used."

Your interviewer is looking for how well you respond to mistakes - we all make them sometimes! Since pipettes are one of the most used tools in the laboratory, you should understand how to use them properly and know the common mistakes. Additionally, you should be able to articulate how to avoid these common mistakes and minimize errors.When pipetting, there are a few common errors that can happen. One of the most common is improperly aligning the pipette tip with the liquid. This can cause inaccuracies in the volume measurement. Another standard error is not properly depressing the plunger to the first stop, resulting in incorrect volume dispensing. It's also important to avoid touching the pipette tip to any surfaces, as this can contaminate the sample or alter the volume measurement. Lastly, it's important to regularly calibrate your pipette to ensure accurate measurements.

As a follow-up to the inspection question, what if you encounter a documentation error before the inspection? Is there a time when manipulating data is acceptable?

"I have never manipulated data, nor is there a time when it would be considered acceptable. Data integrity is important to me and the field as a whole. Good science comes from good, honest data. If I spotted a documentation error before the inspection, I would report it to my supervisor."

It is never acceptable to manipulate data in this field, so the interviewer could be interested in the way you answer the question in terms of integrity. Your interviewer might also be looking for how you respond to a somewhat stressful question as this touches on ethics and legality issues. If you spot a documentation error before your inspection, it's essential to bring it to the attention of the appropriate parties as soon as possible. This will allow for the necessary corrections and ensure the inspection is conducted with accurate information. As for manipulating data, it's never acceptable to do so in a fraudulent or unethical manner. However, there may be situations where data needs to be adjusted for legitimate reasons, such as correcting errors or ensuring accuracy. It's important to always approach data manipulation with transparency and integrity, following the company's policies and procedures.

If you find yourself in a situation where your laboratory finds contamination, what troubleshooting steps would you take?

"This has happened to me in the past. In several PCR runs, I noticed the internal control was unusually positive in all samples. What was especially alarming is that it was also positive in the negative control samples. This occurred on several runs on all of the machines leading me to believe it was a contamination issue rather than a specific failure related to reagents, equipment, or human error. I added Uracil-DNA Glycosylase (UNG) to the PCR assay to prevent carryover contamination between PCRs. This technique proved to be successful in future runs."

First, don't ask what type of contamination! It is irrelevant since the interviewer wants to know if you have experience dealing with contamination (most laboratory professionals do) and how you controlled it. Reflect on a time when you dealt with contamination in the lab. If you are early in your career, then think about your experience with this as a student and what you might have learned from instructors and other professionals.It is best to explain that if contamination is detected in your laboratory, the first step would be to pinpoint the source of the issue. Describe how you would carefully review laboratory procedures, equipment, and materials used during the testing process to identify any potential sources of contamination. From there, you would take swift action to eliminate or reduce the contamination. This could involve cleaning and disinfecting equipment, removing contaminated materials, or adjusting your testing procedures to prevent future contamination. Then explain how you would also conduct a thorough review of the quality control processes to ensure they are effective in detecting any potential contamination in the future.

What do you know about our organization, and what makes you want to work with us?

"I have followed this organization and its evolution for seven years. Over the last several years, I've seen you continue to make incredible strides in research, and I love how you always lead by example. In addition to your work, I understand that you are heavily involved in your local community and find ways to partner, uplift, and support others in new and creative ways. As a scientist who values community, I am extremely inspired by your model and would love to bring my skills and passion to the team."

With any job interview, it is crucial to understand the organization to which you are applying, as well as what motivates you to work there. Visit the organization's website to learn key information, such as studies they've been involved in, specialties, and community impact. Knowing how the organization started, who started it, the mission and vision statement, and their core values will impress the interviewer. Consider looking for any headlines they have made recently for additional context.

Why are you looking for a new job?

"There are a few reasons I am looking for a new job. I was working as a Clinical Trial Assistant to gain experience while obtaining my Clinical Research Associate certification. After completing my certification and gaining two years of experience, I feel ready to further my career as a CRA. However, no positions are open at my current facility, and will not be for several years. I do not want to wait that long to advance my career, so I applied to your organization since you have an incredible reputation and encourage and promote professional growth."

When an interviewer asks you why you are looking for a new job, you want to respond honestly and tactfully. Focus on the positive reasons for wanting to make a change, such as seeking growth opportunities or a better work-life balance, rather than solely on the negative aspects of your current job. It's also important to avoid speaking badly about your current employer or colleagues, as this can reflect poorly on your professionalism and attitude. Remember to keep your response concise and relevant to the position you are interviewing for, showcasing how your career goals align with the company's mission and values.

What is your best piece of advice you would give to someone who is interested in pursuing a career as a Clinical Research Associate?

"My best piece of advice I would give someone interested in this line of work is to make sure they take a training course recognized by the Association of Clinical Research Professionals or the Society of Clinical Research Associates. I would further explain that it is not required to take a course and be certified to get a job as a CRA, but it helps secure a good job in the long run. Also, there are a lot of courses that are offered that are not recognized by the two associations, which I would steer away from."

The interviewer asks what advice you would give to someone interested in pursuing a career as a Clinical Research Associate because they want to know if you have any insights or personal experience to offer others. They also want to gauge your passion and dedication towards this career path and your ability to provide valuable guidance to those considering it. It's important to be honest and thoughtful when answering this question, as the interviewer is looking for someone knowledgeable, enthusiastic, and capable of mentoring others.

What is your favorite stage of a clinical trial and why?

"My favorite stage of a clinical trial and what brings me the most excitement is the data analysis phase, where I get to see the impact of my work and draw conclusions that can inform future research. I have a very analytical mind and enjoy uncovering patterns and trends based on the data I receive."

The interviewer may ask about your favorite part of a clinical trial to gain insight into your interests and strengths in the field. It can also help them understand what motivates you and if you are a good fit for the role. Additionally, your answer can provide valuable information about your approach to research and your ability to work collaboratively with a team. As you know, clinical trials typically consist of several parts, including the planning and design phase, the recruitment and enrollment of participants, the administration of the intervention or treatment being tested, and the collection and analysis of data. Additionally, there may be follow-up periods to assess any long-term effects of the treatment. The trial may also involve a control group, which receives a placebo or standard treatment, and a blinded or double-blinded design to minimize bias. Describe your favorite part and why you enjoy that specific aspect of a clinical trial.

How did you hear about this position?

"I heard about the position from your website. I have always wanted to work for your organization and signed up for email alerts when a position opened up. I was excited to get an email only a few days after signing up for the alert, and I appreciate you considering me for the position."

Interviewers often ask how you heard about the position to understand which recruitment channels are most effective for their company. By knowing where candidates are hearing about their job openings, they can allocate their recruitment budget and resources more efficiently in the future. Additionally, if you heard about the position through a referral, it can reflect positively on your character and work relationships. It shows that you have a network and are capable of building professional connections.

What is your greatest strength?

"I would say that my greatest strength is adaptability. I am adaptable in my communication style, how I support others, and in prioritizing tasks. I can remain confident and positive when things change, even when it is a difficult or unexpected pivot."

The interviewer asks about your greatest strength as a Clinical Research Associate to better understand your skill set and how it aligns with the position's requirements. This question also allows them to see how you view yourself and how confident you are in your abilities. It is essential to prepare a thoughtful and honest response that highlights your strengths and how they can benefit the company. As a Clinical Research Associate, several strengths are highly valued in the field. Firstly, attention to detail is crucial as you will be responsible for ensuring accuracy and compliance in all aspects of the research process. Additionally, strong communication skills are necessary to effectively collaborate with study coordinators, investigators, and other team members. Being organized and able to manage multiple tasks simultaneously is also important in this fast-paced environment. Finally, a strong work ethic and dedication to the study's success are essential qualities to possess as a Clinical Research Associate. After describing your greatest strength, remember to provide specific examples to support your answer and demonstrate your expertise in the field.

What made you choose clinical research as a career path?

"For as long as I can remember, I have been passionate about solving complex challenges - especially regarding public health. Over the years, I've found that I do my best work and make greater contributions behind the scenes. My mentor in college saw this potential in me as well and encouraged me to pursue clinical research. After my first internship, I was sold! I'm grateful to have a career that balances my personality with my professional goals, all while giving back and supporting the global community."

The interviewer asks why you chose clinical research as a career path to better understand your motivations and interests. Your answer can provide insight into your passion for the field, your previous experiences, and how you see yourself contributing to the industry. Most who enter this field do so for the following reasons: (1.) To help others improve their quality of life, (2.) To participate in drug development, (3.) To be scientifically challenged, or (4.) To work in an industry that is constantly evolving. Overall, the interviewer wants to know that you are committed to the field and genuinely desire to make a positive impact through your work.

Describe your experience writing a standard operating procedure (SOP).

"I designed, optimized, and validated a new DNA extraction assay to be utilized on several downstream applications. This required careful record keeping of preliminary protocols and data and the final SOP once optimized. My experience writing an SOP was both challenging and rewarding. It required a lot of research and attention to detail, but it was worth it. I learned a lot about the importance of standardization and clear communication, and I feel more confident in my ability to create effective SOPs in the future. The process also helped me develop my writing and organizational skills, which will be valuable in many other areas of my work. Overall, I'm glad I had the opportunity to write an SOP, and I look forward to applying what I've learned in my future projects."

Following SOPs is a part of the daily routine of a Clinical Research Associate. The interviewer is asking about your experience writing SOPs as a Clinical Research Associate because it could be an essential part of the job you are interviewing for. SOPs, or Standard Operating Procedures, ensure that research studies are conducted consistently and accurately. As a Clinical Research Associate, you must be familiar with creating and implementing SOPs to ensure that study protocols are followed correctly. Having excellent communication skills to liaise with study site staff and ensure they follow the procedures is also essential. Overall, having experience writing SOPs would demonstrate your ability to perform well in this role.

What is your experience with cell culture and what types of cell culture-based assays have you performed?

"I have maintained HeLa cell lines and performed CCID50 and plaque assays to determine any residual infections virus after inoculating cells with varying amounts and different virus strains. These assays were important to the overall research question of whether or not a particular agent killed or lowered cell viral loads."

Whether it's clinical research or a purely scientific research laboratory, you are likely to work with cells. The interviewer asks about your experience with cell culture and the types of cell culture-based assays you've performed to assess your suitability for the job. They want to know if you have the necessary skills and knowledge to handle the responsibilities of the position, such as maintaining cell lines, performing cell-based assays, and troubleshooting technical issues. Additionally, the interviewer is interested in understanding the depth and breadth of your experience in cell culture, which could influence their decision to offer you the job. Overall, it's essential to be prepared to discuss your cell culture experience and provide specific examples of your work in this area during the interview.

How do you feel about supervising others and their work?

"I thoroughly enjoy supporting others, especially when I can offer insight or guide them. In my current lab, I oversee a team of four junior researchers. I meet with them biweekly to review their progress, learn about their experiences, hear their challenges, and offer coaching and support. I have found that I enjoy my supervisory role as much as I enjoy my research!"

As a Clinical Research Associate, you might be required to supervise a few people or a whole team. It is also possible that the interviewers want the person they hire to grow into more of a leadership role. When preparing your answer to this question, focus on your team management and leadership skills and your ability to guide and mentor others. If you do not have much experience supervising others and their work, reflect on a good supervisor you have had and what they did - or didn't do - to support you and push you to do well. Your response can be in or out of a lab - just be sure to provide an enthusiastic answer.

Give an example of a time you trained someone on a procedure. What went well and what did you learn from the experience?

"Recently, I had the opportunity to train a new lab technician on a complex laboratory procedure. To ensure their success, I broke down the process into clear, step-by-step instructions and provided them with helpful resources, such as a written guide and a demonstration video. I also encouraged them to ask questions along the way and provided hands-on training.Through this experience, I learned that being adaptable and catering to each individual's learning style is crucial for success. While some people benefit from hands-on training, others prefer to read through instructions on their own first. It's also important to periodically check in with the trainee to see if they have any questions or need additional support.Overall, the training was a success, and the technician was able to effectively execute the procedure. Being able to effectively train others on laboratory procedures has given me the confidence to take on future training opportunities."

Training others in laboratory procedures is a task that will likely occur as a Clinical Research Associate. Your response not only allows the interviewer to assess your personality and how you approach training, but also your technical skills based on terms and approaches used in training. If you do not have a lot of experience training others, think of a positive and effective experience you've had with someone teaching you.

Give me example of a large project or task you completed, the steps you took, and the overall outcome.

"After graduate school, I worked in the development department for a scientific research nonprofit organization. We ran our biggest fundraising campaign towards the end of the year, and I was solely in charge of the major donor mailing for the campaign. I was given the general parameters, an Excel document of potential recipients, and a tight deadline. My team was under pressure, so I didn't want to add more stress. I distributed a detailed outline of who needed to review what and by when, and I followed up by personally checking in with each stakeholder in a calm, positive way. I requested a team of volunteers from our community coordinator and called them in when all the components were ready to assemble. Together, the team of volunteers and I prepared over 400 separate mailings that included five personalized items in each mailing - and I managed to complete the project from start to finish two days before the deadline! Much of the project's success can be attributed to being communicative, positive, and seeking external help to alleviate internal pressure. It was a huge success!"

The interviewer wants to know how you plan out and break down a big project. They are also interested in gauging how well you delegate tasks or seek support from others, making this an opportunity to demonstrate a balance of thriving as an independent self-starter that also succeeds in collaborative teamwork environments. Additionally, the interviewers are interested in determining if you are a good fit for the organization's future plans which may require you to start working on some new projects. Don't feel confined to using an example directly in the field. A response from another profession or even from your education can be equally powerful if it is fairly recent and you outline it well. When preparing your answer, be sure to explain the project enough to give them an idea of its scope without oversharing. Also, balance how you speak to each point - you don't want to downplay the process or overall outcome.

How do you prioritize when you have multiple deadlines?

"Before I leave work each day, I take a few moments to review my calendar for upcoming deadlines and create a manageable list of top priorities for the following morning. This allows me to get right to it the next day without needing to figure out what to do first. When I first get a project, I update my calendar with the full task timeline from start to finish and incorporate a workflow to update me with reminders and changes automatically. I always confirm the priority level of a project with my supervisor using a color-code system, so I can make adjustments as needed without pulling her in too often. Of course, when I foresee a bottleneck of tasks and deadlines, I loop my supervisor in to help brainstorm how to make adjustments."

Your interviewer is interested in learning about your process for completing and prioritizing several tasks simultaneously. You want to demonstrate your ability to navigate this task while recognizing when it is necessary to involve your supervisor. Be mindful that priorities might be fluid in certain conditions, so be sure to indicate your ability to assess and adapt as needed. Your response also demonstrates your ability to handle stress and pressure, which is common when working as a Clinical Research Associate. Prioritizing tasks effectively is essential in any job, but it's vital in roles where multiple projects happen simultaneously in the lab. By asking about prioritization, the interviewer is trying to determine if you can handle the demands of the job and if you have the skills necessary to succeed in the role.

A colleague asks you to ensure the glassware is sterilized for next week's experiments. What do you do?

"Many labs I've worked in have trained staff that autoclaves all glassware. After using it in the lab, I rinse it with DI water and then send it for autoclaving, which kills viruses and bacteria. If I am in a situation where a colleague asks me to ensure that the glassware is sterilized for next week's experiments, I make sure to follow the proper protocol. First, I thoroughly clean the glassware with soap and water, carefully removing any debris or residue. Then, I sterilize the glassware using an autoclave or other sterilization method, ensuring it is completely free of bacteria or other harmful contaminants. It's important to take these precautions to ensure the accuracy and safety of our experiments."

During your interview, you may be asked how you take responsibility and follow through on tasks assigned by colleagues. As a Clinical Research Associate, if a colleague asks you to ensure the glassware is properly sterilized for next week's experiments, it is vital to communicate effectively and pay close attention to detail. Confirm the specific protocol for sterilization with your colleague and make a plan to complete the task in a timely manner. By doing so, you can help prevent any potential contamination or errors in the experiments.

If your laboratory needs a new piece of equipment, what steps would you take and what do you consider when bringing new equipment aboard?

"In my current position, I was tasked with finding a new centrifuge. Based on internet research, in addition to asking colleagues in nearby departments, I decided on three companies and centrifuges to fulfill our internal commitment. I completed all necessary admin paperwork to get the centrifuge ordered. When delivered, I followed all instructions provided by the company and the technician that delivered the product to ensure proper installation and running of the equipment."

Procurement of reagents and equipment is a common yet often overlooked responsibility of a Clinical Research Associate. Like most other things in the field, it's necessary to understand what type of organization you are applying for since different organizations handle procurement differently regarding finding, getting quotes, and budgets. Your interviewer will likely ask you situation-based questions to understand how you outline your process and how well you can explain your steps to others. Provide an example illustrating your experience in bringing new equipment into the lab.

When your boss asks you to design an assay to detect a mutation using PCR, provide a list of 3 things you will do before testing and optimizing begin.

"In this case, I would first review current literature to understand what is currently being used to test the specific mutation in question. Then, I would evaluate the necessary and available equipment, reagents, and resources needed. Finally, I would write a protocol for the procedure."

Always be prepared for the interviewer to ask you situation- and knowledge-based questions to understand how you outline your process and how well you can explain concepts to others. As new and improved assays are constantly being developed and implanted in laboratory research and clinical settings, the interviewer wants to see what three things you will do before testing begins. Before you respond, ask the interviewer whether or not this is a diagnostic assay with FDA regulations so the interviewer knows that you understand the difference between clinical and research. Then you will be prepared to formulate your response.

This position requires traveling approximately 50% of the time, often on short notice. Will this be an issue for you?

"No, traveling will not be an issue for me if hired for this position. I saw this was a requirement in the job description, and I'm ready and willing to go wherever the job takes me. I'm quite flexible and can adjust my schedule accordingly to accommodate any travel requirements that may arise. Rest assured, I will always be ready to go, even on short notice."

As a Clinical Research Associate, you will often be required to travel for your job as you are responsible for monitoring clinical trials at various research sites. This involves traveling to different locations to ensure the trials are conducted according to protocol and regulations. You may also need to travel to meet with sponsors, investigators, and other stakeholders. The ability to travel is a crucial aspect of the job, as it allows you to ensure the safety and efficacy of the clinical trials you oversee. The interviewer wants to see that you understand the travel demands of the job before committing to it.

When making a 1L 1X PBS solution from the stock 10X concentration, how would you do it; which formula would you use?

"100mL of 10X PBS and 900mL water is needed to make a 1X 1L solution. I would use the formula C1V1 = C2V2 where C1 equals the initial concentration of the solution, V1 equals the initial volume of the solution, C2 represents the final concentration of the solution, and V2 is the final volume of the solution."

Your interviewer will ask situation- and knowledge-based questions to understand how you outline your process and how well you can explain concepts to others. In this case, buffers and reagents come at concentrations that may or may not be suitable for direct use. This is a standard calculation used routinely as a Research Associate. Remember, you do not need to ask what PBS is as it's irrelevant to the result, and it's a common reagent in most laboratories.

How do you manage your time when under pressure?

"Balancing multiple projects comes with the territory in clinical research, so I build out my time management and organization techniques in anticipation of being under pressure. When I'm feeling the stress build up, I will set a brief timer - 5 to 10 minutes - and do a brain dump. Usually, that means that I'm either writing down all the things I'm thinking of and aware need to happen, or I might be doodling a visual of what needs to be done. I don't stop to process during this time; I get it all out on paper. When the timer is up, I take a moment to look over what I've written down. Seeing it all on paper helps me visually organize, prioritize, and strategize in a way I can't do all in my head. This helps me see which tasks require what time and where I can consolidate to save time. Sometimes, it feels like stopping for 5 to 10 minutes is impossible, but it always helps me manage my time and tasks significantly better overall!"

As a Clinical Research Associate, you might have multiple projects simultaneously, which can be stressful. This highly demanding field also creates a stressful environment due to the many sites, study requirements, and deadlines you must account for. Since this is an everyday reality in the profession, your interviewer wants to ensure you are prepared and equipped to navigate those pressures while keeping things moving along. Think about the time management, organization, and prioritization techniques you employ when stressed. Then explain how you manage your time under pressure and how you will benefit the organization if hired.

What is your greatest weakness? What are you doing to improve it?

"My greatest weakness is getting heavily absorbed in my work. I love what I do, and sometimes I have difficulty leaving my work at work and balancing out things and time for myself. Over the last year, I have been working more on incorporating routine self-checks, focusing on stress-relieving activities, and establishing boundaries so I don't find myself researching a project at midnight when I should be sleeping. I have also decided to leave my work at the door when I leave for the day and pick it back up on my next shift."

You want to be honest when answering a question about your greatest weakness and be mindful of what truth you are sharing. You might know that your greatest weakness is realistically snoozing your alarm each morning, but that isn't an answer you want to share. Instead, consider a weakness that doesn't paint you in a light that will deem you unfit for the position. You might also consider a flaw that, in some cases, might be seen as very relatable to others or even perceived as a strength to some. Be sure you also have an action plan for improving on this weakness.

How would you handle an unethical request from a superior?

"Maintaining integrity in clinical research is extremely important, so I would handle this situation very carefully. First, I want to clarify the request to ensure I am not misinterpreting it. I would also want to do that in writing and request a response via email or memo to ensure that I best understand what is being asked of me. Once I understand clearly, I politely indicate my discomfort with the task and suggest an alternative approach. If my supervisor were to persist, I would ultimately seek guidance from a superior."

This question touches on a few components: communication, integrity, and action. When preparing a response, consider the various factors and influences that go into the circumstances, such as potential miscommunication or misinterpretation. If you have an example of a time when you have encountered this in the past, then use it! The interviewer is looking for how gracefully and professionally you might navigate this situation.

Clinical Research Associate Interview Questions

Go Back

1. Do you have any questions for us?
2. What is your experience with following procedure, preparing for, and being involved in a regulatory audit and/or inspections of any kind?
3. What have you done to further your professional development in the past 5 years?
4. How would you respond if a trial participant asked you why they should participate in a clinical trial?
5. What is the difference between accuracy and precision?
6. How do you describe your job to others who are unfamiliar with this line of work?
7. Are you a detail-oriented person?
8. Tell me about the data entry programs you are familiar with.
9. What part of your job is the most rewarding?
10. What is the purpose of a polymerase chain reaction (PCR)? Please provide an example of when you've run one in the past.
11. When receiving a new piece of equipment in the lab, give a brief explanation of what you would do to verify that the equipment works properly for its intended test.
12. In the scenario where your quality control fails, what troubleshooting steps would you take?
13. Give an example of the types of metadata and/or data analysis you are familiar with and have used in previous positions.
14. When your boss asks you to get 5 aliquots each of 5 different samples to deliver to another department, what is being asked and how would you perform the task?
15. How would you describe Good Laboratory Practices (GLP) to a new employee?
16. Suppose you hear that a coworker is talking poorly about you behind your back. How would you respond?
17. Describe a time when you made a pipetting error and what you did to fix it.
18. As a follow-up to the inspection question, what if you encounter a documentation error before the inspection? Is there a time when manipulating data is acceptable?
19. If you find yourself in a situation where your laboratory finds contamination, what troubleshooting steps would you take?
20. What do you know about our organization, and what makes you want to work with us?
21. Why are you looking for a new job?
22. What is your best piece of advice you would give to someone who is interested in pursuing a career as a Clinical Research Associate?
23. What is your favorite stage of a clinical trial and why?
24. How did you hear about this position?
25. What is your greatest strength?
26. What made you choose clinical research as a career path?
27. Describe your experience writing a standard operating procedure (SOP).
28. What is your experience with cell culture and what types of cell culture-based assays have you performed?
29. How do you feel about supervising others and their work?
30. Give an example of a time you trained someone on a procedure. What went well and what did you learn from the experience?
31. Give me example of a large project or task you completed, the steps you took, and the overall outcome.
32. How do you prioritize when you have multiple deadlines?
33. A colleague asks you to ensure the glassware is sterilized for next week's experiments. What do you do?
34. If your laboratory needs a new piece of equipment, what steps would you take and what do you consider when bringing new equipment aboard?
35. When your boss asks you to design an assay to detect a mutation using PCR, provide a list of 3 things you will do before testing and optimizing begin.
36. This position requires traveling approximately 50% of the time, often on short notice. Will this be an issue for you?
37. When making a 1L 1X PBS solution from the stock 10X concentration, how would you do it; which formula would you use?
38. How do you manage your time when under pressure?
39. What is your greatest weakness? What are you doing to improve it?
40. How would you handle an unethical request from a superior?

Clinical Research Associate Interview Questions

1. Do you have any questions for us?

2. What is your experience with following procedure, preparing for, and being involved in a regulatory audit and/or inspections of any kind?

3. What have you done to further your professional development in the past 5 years?

4. How would you respond if a trial participant asked you why they should participate in a clinical trial?

5. What is the difference between accuracy and precision?

6. How do you describe your job to others who are unfamiliar with this line of work?

7. Are you a detail-oriented person?

8. Tell me about the data entry programs you are familiar with.

9. What part of your job is the most rewarding?

10. What is the purpose of a polymerase chain reaction (PCR)? Please provide an example of when you've run one in the past.

11. When receiving a new piece of equipment in the lab, give a brief explanation of what you would do to verify that the equipment works properly for its intended test.

12. In the scenario where your quality control fails, what troubleshooting steps would you take?

13. Give an example of the types of metadata and/or data analysis you are familiar with and have used in previous positions.

14. When your boss asks you to get 5 aliquots each of 5 different samples to deliver to another department, what is being asked and how would you perform the task?

15. How would you describe Good Laboratory Practices (GLP) to a new employee?

16. Suppose you hear that a coworker is talking poorly about you behind your back. How would you respond?

17. Describe a time when you made a pipetting error and what you did to fix it.

18. As a follow-up to the inspection question, what if you encounter a documentation error before the inspection? Is there a time when manipulating data is acceptable?

19. If you find yourself in a situation where your laboratory finds contamination, what troubleshooting steps would you take?

20. What do you know about our organization, and what makes you want to work with us?

21. Why are you looking for a new job?

22. What is your best piece of advice you would give to someone who is interested in pursuing a career as a Clinical Research Associate?

23. What is your favorite stage of a clinical trial and why?

24. How did you hear about this position?

25. What is your greatest strength?

26. What made you choose clinical research as a career path?

27. Describe your experience writing a standard operating procedure (SOP).

28. What is your experience with cell culture and what types of cell culture-based assays have you performed?

29. How do you feel about supervising others and their work?

30. Give an example of a time you trained someone on a procedure. What went well and what did you learn from the experience?

31. Give me example of a large project or task you completed, the steps you took, and the overall outcome.

32. How do you prioritize when you have multiple deadlines?

33. A colleague asks you to ensure the glassware is sterilized for next week's experiments. What do you do?

34. If your laboratory needs a new piece of equipment, what steps would you take and what do you consider when bringing new equipment aboard?

35. When your boss asks you to design an assay to detect a mutation using PCR, provide a list of 3 things you will do before testing and optimizing begin.

36. This position requires traveling approximately 50% of the time, often on short notice. Will this be an issue for you?

37. When making a 1L 1X PBS solution from the stock 10X concentration, how would you do it; which formula would you use?

38. How do you manage your time when under pressure?

39. What is your greatest weakness? What are you doing to improve it?

40. How would you handle an unethical request from a superior?