Can you explain what an excipient is and one of its possible uses?
An excipient is a pharmacologically inactive substance formulated alongside the active pharmaceutical ingredient of a medication. Excipients have various uses. Share your knowledge with the interviewer.
"An excipient is a substance that has no active value that is used with the active ingredient of a pharmaceutical medication. One use of excipients is as a binder. Binders hold the ingredients in a tablet together."
"Excipients are used in the production of a medication for multiple reasons. They have no value as far as an active ingredient, but are used along with the active ingredient. They are often used as fillers. Fillers typically also fill out the size of a tablet or capsule, making it practical to produce and convenient for the consumer to use."
Can you explain a possible problem that may arise with processing tablets?
While there are any number of issues that may arise when processing medications, there are a few that are more common when processing tablets. Those include: capping, lamination, and moddling. Explain what happens during one of this issues.
"One of the problems I can think of that may arise when processing tablets is lamination. Lamination is the term used to describe the separation of tablets into two or more layers."
"There are a few complications that come to mind when I think about tablet processing. Capping is either a partial or complete separation of a tablet top or bottom crown. Another possible problem I can thing of is mottling, which is unequal colour distribution of a tablet."
What is a parenteral medication?
Parenteral medications are sterile dosage forms administered by injections thorough one more layers of the skin. Give the interviewer an example of a parenteral medication or route of administration.
"Parenteral medications are medications that are given through layers of the skin, such as IV therapy or an injection. If the medication is administered correctly, it will be sterile."
"Parenterals are any medication that are given through the skin. A Rocephin injection is one example. Also, intravenous medications are considered parenterals."
What type of pharmaceutical excipient is carboxymethyl cellulose?
Carboxymethyl cellulose is an example of a disintegrant. Disintegrants are added to drug formulations, which assist to breakup tablets and contents of capsules into smaller particles for quick dissolution when it comes in contact with water in the GI tract.
"Carboxymethyl cellulose is a disintegrant excipient. It helps to break down medications in the gastrointestinal tract."
"It is classified as a disintegrant. Disintegrants, ideally, exhibit poor solubility and poor gel formation capacity. They are useful in the digestive tract where they mix with water and hellp to break the contents of capsules or tablets into pieces that are smaller are more easily absorbed."
Why did you choose a career in pharmaceutical manufacturing?
There are many career opportunities within the pharmaceutical industry. Questions like this give the interviewer an opportunity to know you. Share your thoughts about your career choice.
"I always wanted a career in the healthcare industry, but I wasn't sure if a hospital setting was for me. I did some research into different health-related career opportunities and really felt like working with pharmaceutical manufacturing would be an opportunity for me to provide a way to help people."
"I have always been fascinated with chemistry. I also wanted to do something to provide care for others. I felt like manufacturing pharmaceuticals would allow me to do both. I have never considered any other career."
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